Now I know this is dependent on the PC to a big extent but I've been out of the loop with modern hardware for a few years. I have a project where a large 3D texture might solve things, we're talking maybe 512^3 but probably 8-bit, single channel. Memory wise this is not a big deal (it's not a game project and there are not lots of models or textures in use) but I really don't know if it would be supported on a typical PC (not a games rig). Or if it would slow things to a crawl... or once it's in the GPU memory it would not be unduly performance-limiting?
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